{"id":410,"date":"2019-12-05T02:16:04","date_gmt":"2019-12-05T02:16:04","guid":{"rendered":"https:\/\/drnat.com\/nd\/?p=410"},"modified":"2019-12-05T02:26:47","modified_gmt":"2019-12-05T02:26:47","slug":"prp-and-the-shoulder","status":"publish","type":"post","link":"https:\/\/drnat.com\/nd\/prp-and-the-shoulder\/","title":{"rendered":"A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort."},"content":{"rendered":"
PLoS One.<\/a> 2016 Feb 5;11(2):e0147842. doi: 10.1371\/journal.pone.0147842. eCollection 2016.<\/div>\n
Wesner M<\/a>1, Defreitas T<\/a>1, Bredy H<\/a>1,2, Pothier L<\/a>1, Qin Z<\/a>3, McKillop AB<\/a>3, Gross DP<\/a>1,2,3.<\/div>\n
\n

Author information<\/a><\/h3>\n
 <\/div>\n<\/div>\n
\n

Abstract<\/h3>\n
\n

OBJECTIVE:<\/h4>\n

This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy.<\/p>\n

DESIGN:<\/h4>\n

Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consenting patients treated at an academic sports medicine clinic were randomly assigned to either a PRP or placebo control group.<\/p>\n

SETTING:<\/h4>\n

The Glen Sather Sport Medicine Clinic, Edmonton, Canada.<\/p>\n

PATIENTS:<\/h4>\n

The RCT included 9 participants with rotator cuff tendinopathy. The cohort study included 178 participants with a variety of tendinopathies.<\/p>\n

INTERVENTIONS:<\/h4>\n

Patients receiving PRP were injected with 4 ml of platelets into the supraspinatus and\/or infraspinatus, while patients in the placebo group were injected with 4ml of saline. All participants undertook a 3-month standardized, home-based, daily exercise program.<\/p>\n

MAIN OUTCOME MEASURES:<\/h4>\n

Participants in the RCT were re-evaluated 3, and 6 months post-injection. Change scores before and after injection on pain, disability and MRI-documented pathology outcomes were compared. In the cohort study, pain and disability were measured at 1, 2 and 3 months post-injection.<\/p>\n

RESULTS:<\/h4>\n

For the RCT, 7 participants received PRP and 2 received placebo injections. Patients receiving PRP reported clinically important improvements in pain (>1.5\/10 on VAS), disability (>15 point DASH change), and tendon pathology while those receiving placebo injections did not. In the observational cohort, statistically and clinically significant improvements in pain and disability were observed.<\/p>\n

CONCLUSION:<\/h4>\n

This pilot study provides information for planning future studies of PRP effectiveness. Preliminary results indicate intratendinous, ultrasound-guided PRP injection may lead to improvements in pain, function, and MRI-documented tendon pathology.<\/p>\n

TRIAL REGISTRATION:<\/h4>\n

Controlled-Trials.com ISRCTN68341698.<\/p>\n<\/div>\n<\/div>\n

 <\/p>\n

Orthop Traumatol Surg Res.<\/a> 2016 Feb;102(1):47-52. doi: 10.1016\/j.otsr.2015.11.002. Epub 2016 Jan 7.<\/div>\n","protected":false},"excerpt":{"rendered":"

PLoS One. 2016 Feb 5;11(2):e0147842. doi: 10.1371\/journal.pone.0147842. eCollection 2016. Wesner M1, Defreitas T1, Bredy H1,2, Pothier L1, Qin Z3, McKillop AB3, Gross DP1,2,3. Author information   Abstract OBJECTIVE: This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy. DESIGN: Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consenting […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","ngg_post_thumbnail":0,"footnotes":""},"categories":[8,10],"tags":[],"yoast_head":"\nA Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. - Dr. Nathan Ehrlich, N.D.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/drnat.com\/nd\/prp-and-the-shoulder\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. - Dr. Nathan Ehrlich, N.D.\" \/>\n<meta property=\"og:description\" content=\"PLoS One. 2016 Feb 5;11(2):e0147842. doi: 10.1371\/journal.pone.0147842. eCollection 2016. 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