\n
PURPOSE:<\/h4>\n
This study was performed to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given an intra-articular injection of platelet-rich plasma (PRP), hyaluronic acid (HA) or ozone gas.<\/p>\n
METHODS:<\/h4>\n
A total of 102 patients with mild-moderate and moderate knee OA who presented at the polyclinic with at least a 1-year history of kneepain and VAS score ?4 were randomly separated into three groups. Group 1 (PRP group) received intra-articular injection of PRP \u00d7 2 doses, Group 2 (HA group) received a single dose of HA, and Group 3 (Ozone group) received ozone \u00d7 four doses. Weight-bearing anteroposterior-lateral and Merchant\u2019s radiographs of both knees were evaluated. WOMAC and VAS scores were applied to all patients on first presentation and at 1, 3, 6 and 12 months.<\/p>\n
RESULTS:<\/h4>\n
At the end of the 1st month after injection, significant improvements were seen in all groups. In the 3rd month, the improvements in WOMAC and VAS scores were similar in Groups 1 and 2, while those in Group 3 were lower (p < 0.001). At the 6th month, while the clinical efficacies of PRP and HA were similar and continued, the clinical effect of ozone had disappeared (p < 0.001). At the end of the 12th month, PRPwas determined to be both statistically and clinically superior to HA (p < 0.001).<\/p>\n
CONCLUSION:<\/h4>\n
In the treatment of mild-moderate knee OA, PRP was more successful than HA and ozone injections, as the application alone was sufficient to provide at least 12 months of pain-free daily living activities.<\/p>\n
LEVEL OF EVIDENCE:<\/h4>\n
Therapeutic study, Level I.<\/p>\n<\/div>\n<\/div>\n
\n
KEYWORDS:<\/h4>\n
Hyaluronic acid; Intra-articular injection options; Knee osteoarthritis; Ozone; Platelet-rich plasma<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
Knee Surg Sports Traumatol Arthrosc. 2016 Apr 7. [Epub ahead of print] Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Duymus TM1, Mutlu S2, Dernek B3, Komur B2, Aydogmus S4, Kesiktas FN5. Author information Abstract PURPOSE: This study was performed to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","ngg_post_thumbnail":0,"footnotes":""},"categories":[8,7],"tags":[],"yoast_head":"\n
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